LIPTIDE: THE ARTIFICIAL VIRUS

LipTide is the first of its kind. Technically speaking, LipTide is a synthetic peptide nanoparticle largely composed of peptides. This construction sets it apart from the vectors of the past

LipTide’s peptides bind the payload at its core and protrude from the surface, enabling them to engage with receptors abundant on specific cells.

This peptide-receptor binding triggers the cell to take in the nanoparticle. Once inside the cell, the lipid component of LipTide enables rapid and effective release of the nucleic acid payload.

The targeted delivery holds the key to LipTide’s groundbreaking potential, providing:

Higher delivery rates and specificity than traditional liposomal vectors

Greater versatility and lower safety risks than viral vectors

High tolerability making it suitable for regular repeat dosing

THE VECTOR CUSTOM-BUILT FOR YOU

LipTide is a flexible delivery system. Different surface peptides can be used to bind with different types of target cell. Different payloads can be carried to perform a range of different tasks, including gene editing and mRNA vaccines. Different administration methods can be used, such as injection into the bloodstream or inhalation into the lungs.

Payload

Any type of
gene therapy
can be delivered

Peptide

Customised
for uptake in
target cells

Lipid

Customised for
release once
taken in

Delivery

Targeted at
the right part
of the body

DELIVERING IN PRACTICE

LipTide has successfully delivered gene therapy across a broad range of applications. We are now taking this exciting in vivo data forward to the clinic, both in-house and with our partners.

Targeted delivery to tumours
without leakage to other
organs, especially the liver

Delivery to airway
epithelial cells via
aerosol inhalation

Repeat airway and
systemic delivery achieving
enhanced efficacy

Ocular delivery to
ensure success of
glaucoma surgery

Effective suppression of
tumour growth by silencing
a key oncogene

Flexible delivery of siRNA,
mRNA and DNA payloads

Altogether, LipTide contains all the components for efficient, targeted and well-tolerated delivery, making the promise of gene therapy one step closer to becoming a reality